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(113) Kuhn, P., Thiem, S., Steinert, M., Purvis, D., Lugmayr, V., Treutlein, U., Plobner, L. , Leiser, R.-M., Hust, M. and Dübel, S. (2017). (81) Fuchs, M., Kämpfer, S., Helmsing, S., Spallek, R., Oehlmann, W., Prilop, W., Frank, R., Dübel, S., Mahavir, S. and Hust, M. (2014). (2016). Pflegedienst Pflege to Hus Herzlich Willkommen. Fuctional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies. They were obtained from human blood in pre-Corona times and, put simply, contain the information for the basic construction of practically all antibodies that the human species can produce,” explains Kai-Thomas Schneider. (26) Thie, H., Schirrmann, T., Paschke, M., Dübel, S. and Hust, M. (2008). Kontakt. (2020). (2017). In: Handbook of therapeutic antibodies, 2nd ed., Ed. (8) Kirsch, M., Zaman, M., Meier, D., Dübel, S. and Hust, M. (2005). Analysis of single chain antibody sequences using the VBASE2 Fab Analysis Tool. (36) Hust, M., Steinwand, M., Al-Halabi, L., Helmsing, S., Schirrmann, T. and Dübel, S. (2009). (75) Steinwand, M., Droste, P., Frenzel A., Hust, M., Dübel, S. and Schirrmann, T. (2014). 38106 Braunschweig (70) Zhou, M., Meyer, T., Koch, S., Koch, J., Brill, B., von Briesen, H., Benito, J.M., Soriano, V., Haberl, A., Bickel, M., Dübel, S., Hust, M. and Dietrich, U. Generating recombinant antibodies for research, diagnostics and therapy using phage display. (144) Laureano, A.F.S., Zani, M.B., Sant'Ana, A.M., Tognato, R.C., Lombello, C.B., do Nascimento, M.H.M., Helmsing, S., Fühner, V., Hust, M. and Puzer, L (2020). (67) Al-Halabi, L., Balck, A., Michalzik, M., Fröde, D., Büttgenbach, S., Hust, M., Schirrmann, T. and Dübel, S. (2013). Persistence of SARS-CoV-2 specific B-and T-cell responses in convalescent COVID-19 patients6-8 months after the infection. Human-like antibodies neutralizing Western equine encephalitis virus. Cetuximab (Erbitux). Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz. A., Schirrmann, T., Dübel, S. and Hust, M. (2013). Funktionales Proteom-Display zur Identifikation von Biomarkern. There, SARS-CoV-2 viruses are used to test whether the antibodies can block these viruses. and Hust, M.. (121) Zantow, J., Moreira, G.M.S.G., Dübel, S. and Hust, M. (2018. Michael Hust weiß, wovon er redet, wenn er über die Borreliose spricht. Generation and characterization of protective antibodies to Marburg virus. Mating antibody phage display with proteomics. and Dübel, S. (2018). (71) Jäger, V.,  Büssow, K., Wagner, A., Weber, S., Hust, M., Frenzel, A. and Schirrmann, T. (2013). (64) Meyer, T.,  Schirrmann, T., Frenzel, A., Miethe, S., Stratmann-Selke, J., Gerlach, G.F., Strutzberg-Minder, K., Dübel, S., and Hust, M. (2012). Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B. Antibody Phage Display. Oligopeptide M13 Phage Display in Pathogen Research. Phage display, Ed: Lim, T.S. Technische Universität Braunschweig Department of Biotechnology 4/1998 - 7/1999 Diploma thesis: "Molekularbiologische Untersuchungen zur Diversität von Diatomeenarten und Nachweis der Expressionsraten von Diatomeen fcp Genen im Wattsediment" (Molecularbiological analysis of diatom diversity and investigations on expression rates of the diatom fcp genes in the Wadden Sea sediments) in the AG Geomikrobiologie of the Institut für Chemie und Biologie des Meeres under the supervison of Prof. W.E. Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. But we know what we are doing it for and what can come out of it. We reached out to Dr. Hust von Technische Universität Braunschweig (Department of Biotechnology). Ihr Ziel ist es, einen universellen Impfstoff gegen von … Selection of recombinant antibodies from antibody gene libraries. m.hust@tu-bs.de. Transient plant production of Salmonella Typhimurium diagnostic antibodies. Journal of Biological Chemistry 293: 8672-8690, (57) Colwill, K., Persson, H., Jarvik, N.E., Wyrzucki, A., Wojcik, J., Koide, A., Kossiakoff, A.A., Koide, S., Sidhu, S., Dyson, M.R., Pershad, K., Pavlovic, J.D., Karatt-Vellat, A., Schofield, D.J., Kay, B.K., McCafferty, J., Mersmann, M., Meier, D., Mersmann, J., Helmsing, S., Hust, M., Dübel, S., Berkowicz, S., Freemantle, A., Spiegel, M., Sawyer, A., Layton, D., Nice, E., Dai, A., Rocks, O., Williton, K., Fellhouse, F.A., Hersi, K., Pawson, T., Nilsson, P., Sundberg, M., Sjöberg, R., Sivertsson, A., Schwenk, J.M., Takanen, J.O., Hober, S., Uhlén, M., Dahlgren, L.G., Flores, A. Johansson, I, Weigelt, J., Crombet, L., Loppnau, P., Kozieradzki, I., Cossar, D., Arrowsmith, C.H., Edwards, A.M. and Gräslund, S. (2011). (78) Hülseweh, B., Rülker, T., Pelat, T., Langermann, C., Frenzel, A., Schirrmann, T., Dübel, S., Thullier, P. and Hust, M. (2014). Mit dieser Technologie können menschliche Antikörper im Reagenzglas generiert werden. In the interview they told us about the search for antibodies at Carolo-Wilhelmina, what antibody libraries are and why teamwork is so important for their research. Expertenpools des Nationalen Ausschuss für den Schutz von für wissenschaftliche Zwecke verwendeten Tieren, Scientific Coordinator of the EC consortium, Member of Verband Biologie, Biowissenschaften und Biomedizin in Deutschland (. Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes. (104) Mendonça, M., Moreira, G.M., Conceição, F.R., Hust, M., Mendonça, K.S., Moreira, Â.N., França, R.C., da Silva, W.P., Bhunia, A.K. Lecturer for molecular biotechnology. Dübel, S. and Reichert, J.M.. (82) Stech, M., Hust, M., Schulze, C., Dübel, S. and Kubick, S. (2014). Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. If we come into contact with a known antigen again, the immune system can react stronger and faster than at first contact. (145) Bertoglio, F., Meier, D., Langreder, N., Steinke, S., Rand, U., Simonelli, L., Heine, P. A., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Ruschig, M., Riese, P., Eschke, K., Kim, Y., Schaeckermann, D., Pedotti, M., Kuhn, P., Zock-Emmenthal, S., Wöhrle, J., Becker, M., Grashoff, M., Wenzel, E. V., Russo, G., Kröger, A., Brunotte, L., Ludwig, S., Fühner, V., Krämer, S. D., Dübel, S., Varani, L., Roth, G., Cicin-Sain, L., Schubert, M., and Hust, M. (2020) SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. ➜ Research projects: The Collaborative Research Centres, Research Groups and Priority Programmes funded by the German Research Foundation (DFG) play a special role. (62) Frenzel, A., Fröde, D., Meyer, T., Schirrmann, T. and Hust, M. (2012). Application of M13 Phage Display for Identifying Immunogenic Proteins from Tick (Ixodes scapularis) Saliva. Antibody Phage Display. Mining gut microbiome oligopeptides by functional metaproteome display. In 1980, the Institute partly moved to the main campus at the TU Braunschweig. (129) Chung, S.Y., Schöttelndreier, D., Tatge, H., Fühner, V., Hust, M., Beer, L.A. and Gerhard, R. (2018). When we are ill, our immune system forms antibodies against the pathogens (antigens). In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S.. (45) Mollova, S., Retter, I., Hust, M., Dübel, S. and Müller, W. (2010). and Aleixo, J.A.. (2016). (102) Kuhn, P., Fühner, V., Moreira, G.M.S.G., Frenzel, A., Miethe, S. and Hust, M. (2016). (46) Steinwand, M., Jordan, S. and Hust, M. (2010). TU Braunschweig is involved in the “PhoenixD” cluster at Leibniz Universität Hannover (LUH), which is researching new optical technologies. Technische Universitat (TU) Braunschweig is a public university situated in the Lower Saxony city of Braunschweig in Germany. Autoren. They then test for inhibition, i.e. Phage display derived therapeutic antibodies. The influence of antibody fragment format on phage display based affinity maturation of IgG. and Hust, M.. (116) Frenzel, A., Kügler, J., Helmsing, S., Meier, D., Schirrmann, T., Hust, M. and Dübel, S. (2017). Antibody Affinity and Stability Maturation by Error-Prone PCR. Phage display, Ed: Lim, T.S. (2016). (69) Miethe, S., Meyer, T., Wöhl-Bruhn, S.,  Frenzel. They have been working in the Corona Antibody Team (CORAT) for several months. Immune libraries from non-human primates (NHP). Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library. Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System. The work now feels like a doctoral thesis on a much larger scale and in less time, which we are all doing together as a team. Functional characterization of two scFv-Fc antibodies from an HIV controller selected on soluble HIV-1 Env complexes: a neutralizing V3- and a trimer-specific gp41 antibody. and Sundberg, E.J. (33) Hust, M., Thie, H., Schirrmann, T. and Dübel, S. (2009). Michael Hust | Metropolregion Hannover-Braunschweig-Göttingen-Wolfsburg | Professor für Biotechnologie bei Technische Universität Braunschweig | 415 Kontakte | Vollständiges Profil von Michael auf LinkedIn anzeigen und vernetzen (21) Jordan, E., Al-Halabi, L., Schirrmann, T., Hust, M. and Dübel, S. (2007). (72) Frenzel, A., Hust, M. and Schirrmann, T. (2013). But what is the best way to look for it? Phage display, Ed: Lim, T.S. (1999). Development of human-like scFv-Fc neutralizing botulinum neurotoxin E. (91) Avril, A., Miethe, S., Popoff, M., Mazuet, C., Chahboun, S., Rassetti-Escargueil, C., Sesardic, D., Thullier, P., Hust, M. and Pelat, T. (2015). Delivery of antibodies to the cytosol - debunking the myths. (2017) The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies. Towards "proteome scale" antibody selections using phage display. (94) Unkauf, T., Miethe, S. Fühner, V., Schirrmann, T., Frenzel, A. and Hust, M. (2016). Epitope Mapping by Phage Display. Email: s.duebel@tu-braunschweig.de Normally, the corresponding approval procedure takes about one and a half years or more. Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. Gene Function Analysis, Ed: Ochs, M.F.. (76) Miethe, S., Rasetti-Escargueil, C., Liu, Y., Chahboun, S., Pelat, T., Avril, A., Frenzel, A., Schirrmann, T., Thullier, P., Sesardic, D. and Hust, M. (2014). Braunschweiger Forscher gehen den Zecken an den Kragen Jüngste Ausgründung aus der TU Braunschweig Wissenschaftler aus Braunschweig haben heute, am 11. Krumbein and PD Dr. Erhard Rhiel. Construction of Human Immune and Naive scFv Libraries. and Hust, M.. (120) Unkauf, T., Hust, M. and Frenzel, A. In: Handbook of Therapeutic Monoclonal Antibodies: From Bench to Clinic, Ed: An, Z. and Strohl, W.. (32) Jordan, E., Al-Halabi, L., Schirrmann, T. and Hust, M. (2009). antibodies from a single cell clone of human blood, are attached to the surface of a phage, a kind of ‘transport virus’. Epitope Mapping via Phage Display from single gene libraries. First lab space was located in the GBF (National Research Centre for Biotechnology, Braunschweig, now: Helmholtz Centre for Infection Reserach). and Hust, M.. (118) Avril, A., Miethe, S., Hust, M. and Pelat, T. (2018). (74) Frenzel, A., Kügler, J., Wilke, S., Schirrmann, T. and Hust, M. (2014). (123) Dübel, S., Hust, M., Kügler, J., Kuhn, P., Frenzel, A., Krah, S. and Zielonka, S. (2018). (19) Pelat, T., Hust, M., Laffly. Supernatant was harvested after 48 h. The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. Even supposedly minor tasks such as ordering materials or sterilizing work equipment are important for research to function. This part, however, is essential for the viruses to dock to the cell. Phone: +49 531 391-5760 International Microbiology 2, 103-110, Stellen der TU Braunschweig Jobbörse des Career Service Merchandising Sponsoring- & Spendenleistungen Drittmittelgeförderte Forschungsprojekte, Semestertermine Lehrveranstaltungen Studiengänge von A-Z Informationen für Erstsemester TUCard, Status GITZ-Dienste Handbuch für TYPO3 (Intern) Corporate Design-Toolbox (Intern) Glossar (DE-EN) Meine Daten ändern Hochschulöffentliche Bekanntmachungen, Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig Postfach: 38092 Braunschweig Telefon: +49 (0) 531 391-0. Anreise “Before Corona, each of us did our own research on his or her own project. Picture credits: Michael Hust/TU Braunschweig. (68) Bertz, A., Wöhl-Bruhn, S., Miethe, S., Tiersch, B., Koetz, J., Hust, M., Bunjes, H. and Menzel, H. (2013). (101) Zantow, J., Dübel, S. and Hust, M. (2016). Journal of Microbiological Methods 38, 69-80, (1) Janssen, M., Hust, M., Rhiel, E. and Krumbein, W.E. Journal of Virological Methods 106, 225-233, (2) Hust, M., Krumbein, W.E. Human antibody gene libraries. Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig Postfach: 38092 Braunschweig Telefon: +49 (0) 531 391-0. “The next step will be clinical trials, which hopefully can start in autumn,” says Stefan Dübel. Research interests Antibody Engineering: - antibodies for diagnostic and therapy with a focus on pathogens on toxins e.g. Immunotherapy of Cancer: Methods and Protocols, Ed. Construction of human naive antibody gene libraries. (128) Beer, L.A., Tatge, H., Schneider, C., Ruschig, M., Hust, M., Barton, J., Thiemann, S., Fühner, V., Russo, G. and Gerhard, R. (2018). Michael Hust (* 1972 in Oldenburg (Oldb)) ist ein deutscher Biologe und Professor für Biotechnologie an der Technischen Universität Braunschweig. (61) Zhang, C., Helmsing, S., Zagrebelsky, M., Schirrmann, T., Marschall, A.L.J., Schüngel, M., Korte, M., Hust, M. and Dübel, S. (2012). (39) Schirrmann, T., Menzel, C., Hust, M., Prilop, J., Jostock, T. and Dübel, S. (2010). Development of human-like scFv-Fc neutralising Botulinum toxin type B. September 2019 die Norden Vaccines GmbH gegründet. They are obtained from immune cells in human blood and stored in small test tubes that can hold about 1.5 millilitres. Therapeutic Antibodies, Ed: Dimitrov, A.S.. (30) Strebe, N., Guse, A., Schüngel, M., Schirrmann, T., Haffner, M., Jostock, T., Hust, M., Müller, W. and Dübel, S. (2009). The conserved Cys-2232 in Clostridioides difficile toxin B modulates oligomerization and receptor binding. Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody. (140) Sellmann, C., Pekar, L., Bauer, C., Ciesielski, E., Krah, S., Becker, S., Toleikis, L., Kügler, J., Frenzel, A., Valldorf,. (60) David, F., Steinwand, M., Hust, M., Bohle, K., Ross, A., Dübel, S. and Franco-Lara, E. (2011). Similar therapies already exist for other diseases such as diphtheria or tetanus. Antibody Phage Display: Antibody Selection in Solution Using Biotinylated Antigens. Once our project was designed, we sought advice from specialists in the field. “Finding such neutralizing antibody candidates was our most important milestone on the way to a passive immunotherapy against Covid-19, but there are still many more steps and tests to be done before the final drug is ready for use,” says Michael Hust. Only after successful clinical trials can the drug reach hospitals and doctors’ practices. Antibody Engineering: Methods and Protocols, Ed: Chames, P.. (65) Wezler, X., Hust, M., Helmsing, S., Schirrmann, T. and Dübel, S. (2012). Spielmannstraße 7 “At the institute we have numerous of these antibody gene libraries. A transplant immunome deep sequencing and screening platform defines a unique targetable epitope fingerprint of multiple myeloma. The antibodies with the best characteristics are then passed on to the Helmholtz Centre for Infection Research (HZI). V., Ruschig, M., Heine, P.A., Rand, U., Klünemann, T., Meier, D., Langreder, N., Steinke, S., Ballmann, R., Schneider, K.-T., Roth, K.D.R., Kuhn, P., Riese, P., Schäckermann, D., Korn, J., Koch, A., Zock-Emmenthal, S., Becker, M., Scholz, M., Moreira, G.M.S.G., Wenzel, E.V., Russo, G., Garritsen, H.S.P., Casu, S., Gerstner, A., Roth, G., Hermann, A., Schirrmann, T., Dübel, S., Frenzel, A., Van den Heuvel, J., Čičin-Šain, L., Schubert, M. and Hust, M. (2020). 9/1999 - 7/2002 PhD thesis: "Rekombinante Antikörper gegen die NIa-Protease des Plum Pox Virus" (Recombinant antibodies against the NIa protease of the plum pox virus) at the Lehrgebiet Molekulargenetik (now Institut für Pflanzengenetik, Abteilung Pflanzenbiotechnologie), Universität Hannover (now Leibniz Universität Hannover) under the supervision of Prof. Dr. H.-J. That is our motivation.”. Human antibodies targeting CD30+ lymphomas. Yotnda, P.. (48) Dübel, S., Stoevesandt, O., Taussig, M.J. and Hust, M. (2010). (124) Russo, G., Theisen, U., Fahr, W., Helmsing, S., Hust, M., Köster R.W. Obtention and engineering of non-human primate (NHP) antibodies for therapeutics. ➜ Research Centers: The research profile of the TU Braunschweig is characterized by several interdisciplinary and cross-faculty research networks, which are organized as centers. Entwicklung von therapeutischen Antikörpern im Reagenzglas. and Reinard, T. (2002). 5/2011 Habilitation (professorial dissertation, venia legendi for biotechnology), appointed as Privatdozent (PD). Ausbildung und Beruf. : 0531 391-5760 E-Mail: m.hust@tu-braunschweig.de - identification of disease related biomarkers (immunogenic oligopeptides) using phage display, - develoment of an anti-tick vaccine (GO-Bio8 project) (Info Video). (49) Schirrmann, T. and Hust, M. (2010). (138) Wenzel, E.V., Roth, K.D.R., Russo, G., Fühner, V., Helmsing, S., Frenzel, A. and Hust, M. (2020). ETH Zürich), M.Arch. (53) Thie, H., Toleikis, L., Li, J., von Wasielewski, R., Bastert, G., Schirrmann, T., Esteves, I. T., Behrens, C. K.,  Fournes, B., Fournier, N., de Romeuf, C., Hust, M. and Dübel, S. (2011). (13) Hust, M., Meysing, M, Schirrmann, T., Selke, M., Meens, J., Gerlach, G.-F. and Dübel, S. (2006). Dübel, S. and Reichert, J.M.. (83) Wilke, S. and Hust, M. (2014). With this information, we can produce them again and again.”, This small tube contains an antibody library with about 10 billion antibody blueprints. P., Sesardic, D. and Hust, M. (2015). In: Antibody engineering, Ed: Kontermann, R. and Dübel, S.. (40) Mersmann, M., Meier, D., Mersmann, J., Helmsing, S., Nilsson, P., Gräslund S.,  Structural Genomics Consortium, Colwill, K., Hust, M. and Dübel, S. (2010). A One-Step Process for the Construction of Phage Display scFv and VHH Libraries. Kai-Thomas Schneider and Nora Langreder are PhD students at the Institute for Biochemistry, Biotechnology and Bioinformatics at the Technische Universität Braunschweig. To support the CORAT consortium they have temporarily put their own projects on hold. Oligomeric forms of single chain immunoglobulin (scIgG). (108) Postel, S., Deredge, D., Bonsor, D.A., Yu, X., Diederichs, K., Helmsing, S., Vromen, A., Friedler, A., Hust, M., Egelman, E.H., Beckett, D., Wintrode, P.L. Sprachen und interkulturelle Kommunikation, Graduiertenschulen und Graduiertenkollegs, Fakultät Architektur, Bauingenieurwesen und Umweltwissenschaften, Fakultät für Elektrotechnik, Informationstechnik, Physik, Fakultät für Geistes- und Erziehungswissenschaften, Institut für Biochemie, Biotechnologie und Bioinformatik, Institut für Chemie und Biologie des Meeres, Institut für Biochemie und Biotechnologie, Abteilung Biotechnologie, Technische Universität Braunschweig, Advances in Experimental Medicine and Biology. Werden Sie Mitglied unserer akademischen Gemeinschaft - bewerben Sie sich an der TU Braunschweig! Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin. Antibody Phage Display. Sehen Sie sich auf LinkedIn das vollständige Profil an. Phage display-derived human antibodies in clinical development and therapy. (5)Department of Biochemistry and Biotechnology, Technical University Braunschweig, 38106 Braunschweig, Germany. since 12/2002 Group leader at the Institut für Biochemie und Biotechnologie, Abteilung Biotechnologie, Technische Universität Braunschweig headed by Prof. Dr. Stefan Dübel. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to known RBD mutations. Initiiert wurde das CORAT Konsortium von Professor Stefan Dübel und Professor Michael Hust vom Institut für Biochemie, Biotechnologie und Bioinformatik der TU Braunschweig. Picture credits: Michael Hust/TU Braunschweig. Wissenschaftler aus Braunschweig haben am 11. Rise and fall of an anti-MUC1 specific antibody. The consortium scientists are confident that they will also be able to find a suitable candidate against the corona virus. However, since SARS-CoV-2 is a novel virus, many people have not yet developed antibodies against it. Massensensitives Sensor-Fließsystem zur CRP-Diagnostik. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S.. (42) Pelat, T., Hust, M. and Thullier, P. (2010). B., Hust, M. and Zielonka S. (in press). Multimerization domains for antibody phage display and antibody production. barton.jessica@mh-hannover.de. (15) Soltes, G., Hust, M., Ng, K.K.Y., Bansal, A., Field, J., Stewart, D.I.H., Dübel, S., Cha, S. and Wiersma, E. (2007). www.bbt.tu-bs.de/Biotech, Technische Universität Braunschweig (16) Jordan, E., Hust, M., Roth, A., Biedendieck, R., Schirrmann, T., Jahn, D. and Dübel, S. (2007). (141) Tundidor, Y., Ponce, L., Chao, L., Solozabal, J., Hust, M., Dübel, S. & Rojas, G. (2020). Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. (24) Hust, M., Toleikis, L. and Dübel, S. (2007). Development of human and macaque antibodies using antibody phage display for the detection of equine encephalitis viruses. (80) Marschall, A.L.J., Zhang, C., Frenzel, A., Schirrmann, T., Hust, M., Perez, F. and Dübel, S (2014). A Multinational Consortium for the Development of Therapeutic Antibodies to Tier 1 Bioterrorism Agents: Protective scFv-Fc Antibody against Marburg Virus derived from Macaque Immune Library. “This is a method of producing antibodies in the test tube without the immunisation of animals,” explains Stefan Dübel, one of the inventors of the method. (2011). (AA), Dipl.-Ing. Email: m.hust@tu-braunschweig.de Parallelized antibody selection in microtiter plates. Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. Phage display, Ed: Lim, T.S. and von Nickisch-Rosenegk, M. (2016). Identification of an epitope in the membrane proximal external region of gp41 targeted by neutralizing antibodies in plasma from an elite controller using an Env-tailored phage display library. Ihr Ziel ist es, einen universellen Impfstoff gegen von Zecken übertragene Krankheiten zu entwickeln. and Hust, M.. (117) Kügler, J., Tomszak, F., Frenzel, A. and Hust, M. (2018). (77) Hust, M., Frenzel, A., Schirrmann, T. and Dübel, S. (2014). Parameters affecting the display of antibodies on phage. A gene library of this kind comprises around 10 billion antibody blueprints. (107) Zantow, J., Just, S., Lagkouvardos, I., Kisling, S., Dübel, S., Lepage, P., Clavel, T. and Hust, M. (2016). Development of recombinant antibodies for biodefense using phage display. (56) Lüders, S., David, F., Steinwand, M., Jordan, E., Hust, M., Dübel, S. and Franco-Lara, E. (2011). Generation and analysis of the improved human HAL9/10 antibody phage display libraries. 18.500 Studierende 1745 seit 3.700 Beschäftigte Jacobsen and Dr. Thomas Reinard. (84) Hust, M., Frenzel, A., Tomszak, F., Kügler, J. and Dübel, S. (2014). Website: https://www.tu-braunschweig.de/bbt/biotech/corat-corona-antibody-team. Improved microtitre plate production of single chain Fv fragments in Escherichia coli. On the influence of vector design on antibody phage display. September 2019, die Norden Vaccines GmbH gegründet. Phone: +49 531 391-5731 Researchers at the Department of Biotechnology of Technische Universität Braunschweig started a research project to develop novel antibody based therapy for coronavirus infections.

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