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Please make a tax-deductible gift today. A life-saver and a game-changer. Alexander started a problem with the specialist at this time. Subscribe to News from Science for full access to breaking news and analysis on research and science policy. After several weeks in recovery, she is home. Tennessee Virginia Benita Alexander on attending Paolo Macchiarinis criminal trial in Sweden Alexander said she attended Macchiarini's trial for closure, seven years after she was Anyone can read what you share. However, Swedish TV reporters also decided to take a close look at Macchiarinis work. Macchiarinis deceit was so outlandish, Vanity Fair sought the opinion of the Harvard professor Ronald Schouten, an expert on psychopaths, who gave this diagnosis-at-a-distance: Macchiarini is the extreme form of a con man. Every year, it gives science a show-business makeover, picking out from the mass of medical researchers those individuals deserving of superstardom. Likewise the whole idea of a wedding: Macchiarini was still married to his wife of 30 years. It relieved a little bit of burden from him.. And because it was built from Castillos own cells, she didnt need to be on any risky immunosuppressant drugs. Dr. Genden also transplanted the cricoid, cartilage cuffing the trachea, supplanting Ms. Seins completely destroyed cricoid. Two investigations, one by the Karolinska Institute and one by Karolinska University Hospital, both found that problems with Dr. Macchiarinis work had been covered up. Anyone can read what you share. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); This site uses Akismet to reduce spam. Sonia Sein, outside her Bronx home, had irreparable damage to her trachea. But as the big day approached, Alexander saw these plans unravel, and finally realised that her lover had lied about almost everything. For other cases, though, doctors say the approach seems promising. https://www.nytimes.com/2021/04/06/health/trachea-transplant-genden.html. By 2011, he was working in Sweden at one of the worlds most prestigious medical universities, the Karolinska Institute, whose professors annually select the winner of the Nobel prize in physiology or medicine. They exchange their vows in Italy. When you implant a synthetic trachea you have one certainty, and that is that the patient will die as a result of it, Delaere says in the email. Its very significant, said Dr. Pierre Delaere, a professor of head and neck surgery at University Hospital Gasthuisberg in Belgium, a trachea specialist not involved in the case. In other countries, more of Macchiarinis patients died after receiving one of his artificial windpipes. At night, when she connected her tracheal tube to a ventilator, the alarm kept going off to let people know that I stopped breathing, said Ms. Sein, who hated causing her family concern. She soon went into full-on investigative journalist mode, and learned that Paolo had, yup lied about everything. Their devastating documentary, which aired in January 2016, led KI officials to reopen the investigation. The theory was simple: let the body do most of the work. It showed department heads and colleagues that they should give Macchiarini special treatment.He could do pretty much as he pleased. Las Vegas Meanwhile, Macchiarinis career soared. 2023 Cinemaholic Inc. All rights reserved. She received another implant at the University College Hospital in London in 2011, after which she was able to be discharged. As it turned out, Macchiarinis patients werent all at deaths door at the time he treated them. The different gender was important, allowing Dr. Genden to use chromosomal analysis to detect whether Ms. Seins cells populated the new trachea. The Karolinska Institute, alleging scientific misconduct, dismissed Dr. Macchiarini, who has long denied wrongdoing. Most protagonists on medical dramas are modern-day heroes. As of late March, 6.5 percent of cells in the donor trachea were hers, with the proportion increasing, he said. He reportedly lied on his CV and research papers to trick patients, causing almost all those who received his inventive trachea transplants (using their own bone marrow cells for organ functionality) to lose their lives. In September, a Swedish prosecutor indicted him on aggravated assault charges related to three trachea transplants. The Karolinska Institute declined to comment for this article, noting only that Dr. Macchiarinis sentence may be appealed. She became close to Paolo as she opened her heart to him about how hard it was for her daughter, then nine years old, to lose her father. However, behind closed doors, Dr. Macchiarini was hiding a secret the procedures were not working. She remained conscious and awake throughout most of them, but unable to breathe. Which left a big, burning question in the air: if Macchiarini was a pathological liar in matters of love, what about his medical research? Paolo Macchiarini is exposed Reality struck Alexander's fantasy romance eight weeks before she was supposed to marry Macchiarini in 2015, when she received an email from a colleague with the subject line saying, "The Pope." At the time, Macchiarini was employed by the prestigious Karolinska Institute in Sweden. He traveled to Illinois to operate on a Korean toddler who was born without a trachea and who was going to be the youngest person to ever receive an artificial one. Plus: A Chicago mother is arrested in connection to the murder of her 6-year-old son; the convicted killer Robert Durst dies at age 78; Theranos founder Elizabeth Holmes sentencing date is set; and an LGBTQ+ rights movement hero is found dead in a Florida landfill. Allegations also emerged that the risky procedure was performed on at least one person who was not critically ill at the time. From November 2011 to June 2014, Paolo Macchiarini gave transplants to Christopher Lyles, Yulia Tuulik, Alexander Zozulya, Yesim Cetir, Hannah Warren (a 3-year-old), Sadiq Kanaan, and Dmitri Onogda. Philippines WebIn reality, Paolo had not worked with the Pope, and he was still married to his wife of 30 years. He took the medical world by storm when he built and transplanted the worlds first bioartificial windpipe two years earlier. As per Macchiarini, who denied the charges against him, wasnt directly accused of killing any of the three patients. Was he conning his patients, his colleagues and the scientific community? Los Angeles The law is supposed to protect individuals from all types of assault, especially when they are powerless, said Dr. Bengt Gerdin, an independent investigator who was hired by the Karolinska Institute in 2015 to look into Dr. Macchiarinis work. It won Dr. Macchiarini international news coverage and cemented his place as a celebrity scientist. And it needs a blood supply to connect to the patients vascular system. Gerdin says the conviction on one count still shows that health care doesnt stand above the law. A 29-year old woman from New Brunswick, New Jersey, posed as a high school student and attended classes for four days before she was caught and arrested. The verdict is the latest development in Macchiarinis stunning fall from grace. Michigan (The patient who survived had the implant removed.). It sounded unbelievable, but Paolo explained to her that he had treated Pope John Paul II in the past, and had become part of a highly classified group of doctors that treated the global elite. This set a dangerous example. We have estimated Paolo Macchiarini's net worth , money, salary, income, and assets. Kentucky Few people at Karolinska, especially among those in power, knew enough about it to appreciate Delaeres claims. Brazil Paolo Macchiarinis income source is mostly from being a successful . Dr. Genden said some scientists told him Youre out of your mind because trying a transplant would risk his reputation. Disgraced surgeon Paolo Macchiarini, who faked research relating to dangerous and largely discredited tracheal transplants, has been handed a 16 month prison sentence in Italy for forging documents and abuse of office. 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Its love of human interest stories makes it sympathetic to unproven therapies. He should be given death penalty! She considered backing out. The trachea has been characterized as a simple tube, but its very complex, Dr. Delaere said. Probationwtf.he killed people knowing damn well that his trachea was bs! He was one of the best con-men I have ever come across, he added. Paolo Macchiarini, in a 2013 photo, implanted synthetic windpipes into multiple patients; all but one died following complications with the implants. Surgeon Paolo Macchiarini was hailed for turning the dream of regenerative medicine into a reality until he was exposed as a con artist and false prophet. What's next for abortion rights in America? In the same year, he earned his medical degree from the, In 1989, he took a course on statistics in clinical research at, In 1994, he obtained a masters degree certificate in organ and tissue transplantation from the, From 2006 to 2009, he was an investigator at the, In June 2008, he performed a trachea transplant on, He performed a synthetic trachea transplant on, In 2012, he was charged in Italy with attempted aggravated fraud. Paolo proposed to her on Christmas Day in 2013. Her friends described him as "Mr. Big" from Sex and the City. Seven of the eight patients Paolo inserted tracheas into have died. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Records show that even with his implant failing, Andemariam was able to complete his Ph.D. before his demise in January 2013. Were going to show up and say, As a student, I had this idea on the back of a napkin and now were ready to go and if it fails, the patient dies and it becomes yet another example of some surgeon who thought he could solve a problem and hes created, instead, just the opposite.. They planned to marry in the Catholic Church in Italy. She pushed through his appointment despite the fact that he had some very negative references and dubious claims on his rsum. The maximum prison sentence for causing bodily harm is 4 years. Acquittal is therefore difficult to defend., But Gerdin says the verdict is not unexpected. As a subscriber, you have 10 gift articles to give each month. The Italian surgeon and his Italian wife Emanuela Pecchia have one son and one daughter. The other patients were treated at hospitals in Barcelona, Florence, London, Moscow, Krasnodar, Chicago and Peoria. He was 63 years old when he was found guilty of causing harm through negligence but not of carrying out an intentional assault and he received a probationary sentence on June 16, 2022. Over the years, this possibility has generated great excitement and a huge amount of research. When the blood vessels were finally connected, the donor trachea began bleeding. A Swedish filmmakers investigative documentary raised further questions, as did a Vanity Fair article detailing how the beguiling surgeon became romantically involved with an NBC producer working on a feature about him and apparently conned her into believing he was divorced and would marry her in a ceremony officiated by the pope and attended by the Clintons, Obamas, John Legend and Elton John. Only four months after Macchiarini operated on Claudia Castillo, his results provisional but very positive were published online by the Lancet. Gerdin determined that Macchiarini committed scientific misconduct, but leadership at the Karolinska Institute ignored the findings and cleared Macchiarini. A 19-year-old Iowa college student allegedly defrauded over 400 donors after raising more than $37,000 by faking a triple cancer diagnosis. By using a patients own cells, Dr. Macchiarini sought to rectify an age-old problem with transplants involving donated organs, which the body sometimes rejects as foreign tissue. They recently published an article in the New England Journal of Medicine admitting that stem cell research has mostly failed to live up to its therapeutic promise. Here are 13 more things about him: Categories: biographical data, crimes, Europe, fitness & health, Italy, Lifestyle, LISTS, Russia, Social Issues, Sweden, Tagged as: Basel, Benita Alexander, Emanuela Pecchia, Paolo Macchiarini. Paolo Macchiarini rode groundbreaking surgeries to global fame, but patients died anyway. However, its imperative to mention that the doctor has only been criminally found guilty of causing bodily harm to a single patient he operated on in Sweden back in 2011 two other charges of assault were dismissed. In part, this is because the field of windpipe repair is a niche area. In late 2014, four doctors in Sweden accused him of fraud, saying that he'd falsified data in six of the papers he had published. Your tax-deductible contribution plays a critical role in sustaining this effort. They should be. Scientific pioneer, superstar surgeon, miracle worker thats how Paolo Macchiarini was known for several years. That meant the donor trachea was accompanied by a blood supply that Dr. Genden connected to Ms. Seins blood vessels. Florida Macchiarini is known for his research fraud and manipulative behavior. What comes next after Texas school shooting? Theres a void in his personality that he seems to want to fill by conning more and more people.. Journals retracted several of his studies. Dr. Gerdin said Dr. Macchiarini was allowed to continue his procedures for so long because the Karolinska Institute and its hospital allowed him to do so. The donor was a young man (identifying details are being withheld to protect privacy). When Macchiarini accused one of them, Karl-Henrik Grinnemo, of stealing his work in a grant application, Hamsten found him guilty. By the time the program aired, in mid-2014, the couple were planning their marriage. Thats something that was new to us, so we need to analyze that, Lundstrm-Kron says. Dressed in a white lab coat or in surgical scrubs, with his broad, handsome face and easy charm, he certainly looked the part. The idea is that scientific progress is driven by the genius of a few. By June 2013, when Paolo took Benita to Venice, Italy, for a romantic weekend, she knew she was falling madly in love. Benita Alexander wearing a wig as she tracked down Paolo in Barcelona [Investigation Discovery]. We have, for example, a growing list of scientific celebrities who have committed major stem cell fraud. Plus: NYC sixth-grader struck and killed by stray bullet; New Hampshire police search for person of interest in double homicide; Fyre Festival fraudster released early from prison; and manhunt continues for escaped Texas prisoner. In 2019, an Italian court said he had forged documents and abused his position, charges unrelated to his trachea work. An alarmingly wide gap has grown between what we expect from stem cells and what they deliver. "I started thinking that if this man is lying to me at such an egregious level, theres no way hes not doing this in his medical life," she told CrimeFeed. Thailand KI fired Macchiarini in March 2016, 2 months after the Swedish documentary came out. Nevada By this year, Dr. Genden said, her condition had deteriorated so that if we delay further, its not going to work out.. But Benita stood by her man and, she said, tried to help him through a tough time. Though Macchiarini was in the public eye, he was able to sidestep the usual rules and regulations. KI commissioned surgeon Bengt Gerdin, a professor emeritus at Uppsala University, to investigate the issue. My wife was the one who said, If you truly believe that people are dying from this and that you could maybe make a difference, you cant just fold up and go home, he said. Since this was radically new, Macchiarini and his colleagues should have tested it on animals first. Wasnt something of this idea behind the special treatment Karolinska gave Macchiarini? Because immunosuppressant drugs are required to prevent rejection of the transplant, cancer patients would be eligible only if free of cancer for five years, Dr. Genden said. Its very exciting, said Dr. G. Alexander Patterson, a professor of surgery at Washington University in St. Louis, who was not involved in the case. He says prosecutors should have pressed for manslaughter charges because Macchiarini had no evidence that the tracheas he implanted would develop into normally functioning organs. The popular press also has a lot to answer for. Any replacement trachea must be rigid or itll collapse like a straw in a McDonalds milkshake, Dr. Genden said. Its fascinating to rewatch as a lesson on how not to report on medical science. Alexander said that Macchiarini told her he was still married to his wife because they were Catholic but were separated. The fact that he could keep all the details straight and compartmentalize these different lives and lies is really amazing.. He was handsome, suave, and a charmer. She met Macchiarini while producing A Leap of Faith and was soon breaking one of the cardinal rules of journalism: dont fall in love with the subject of your story. Hes clearly bright and has accomplishments, but he cant contain himself. Thats what our experience of medical research leads us to suspect. However, he eventually found out about his previous associations. Dont yet have access? Those few patients who are still alive including Castillo have survived in spite of the artificial windpipes they received. On the contrary, they seemed to do more harm than good something that Macchiarini had for years concealed or downplayed in his scientific articles, press releases and interviews. Alexander eventually fell in love with the surgeon, and in 2014, he proposed to her, and they started planning a lavish wedding for the following year. Kevin Belingon This argument didnt wash with those who later investigated the case. Now they were on the wedding guest list: the Obamas, the Clintons, Vladimir Putin, Nicolas Sarkozy and other world leaders. There he reinvented his technique. 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Recently, Ms. Sein, covering the hole with her hand to speak, enthused about having the energy to cook sesame chicken for the first time and how she aims to visit relatives in Puerto Rico. In Macchiarinis case, the hope was that patients could be treated with stem cells taken from their own bone marrow. Support for Macchiarini remained strong, even as his patients began to die. She received a new trachea in January and is believed to be the first patient in the world to undergo a successful direct transplant of a donor trachea.CreditSarah Blesener for The New York Times. The court heard testimony in the case between 27 April and 12 May. The pope, the palace, the world leaders, the famous tenor they were all fantasies. But that, and the fact that he had multiple cell phones for different countries, she chalked up to his demanding job and constant international travel. The court ruling Thursday was in a case involving a Turkish woman named Yesim Cetir, who was the longest surviving of his patients at Karolinska. In January 2016, Macchiarini received an extraordinary double dose of bad press. All rights reserved. She had subsequently undergone six major surgeries and more than 10 smaller procedures, but with all conventional approaches to address her condition exhausted, she made plans to have the tube removed and receive only palliative care. One was a 2-year-old girl named Hannah Warren, on whom hed operated in Peoria, IL, in 2013, according to Vanity Fair. According to the judgment in Macchiarinis case, hospital staff said that Cetir had around 40 near-death experiences and was conscious but unable to breathe for many of them. Macchiarinis lawyer declined to comment to Swedish media today about whether his client would appeal. Castillo was soon back home, chasing after her kids. One of these is the hype surrounding stem cells. Scientists can also suffer from false hope. Surely, he got away with so much because he was considered an exception to the rules with more than a whiff of the Nobel about him. The Italian surgeon and his Italian wife Emanuela Pecchia have one son and one daughter. Indonesia All three patients later died. The transplants, performed on patients from the United States and other countries, were heralded as inaugurating a regenerative medicine revolution. She received another The other side is flat and mobile to move air to the lungs. Paolo dropped another bomb when he told Benita that, despite the fact that both of them had been divorced, Pope Francis would officiate at their wedding. 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February 28, 2022 Emanuela Pecchia is famously known as the wife of popular Swiss-born Italian thoracic surgeon, Paolo Macchiarini. A High-Flying Italian Surgeons Fall From Grace, https://www.nytimes.com/2022/06/17/world/europe/macchiarini-windpipe-surgeon-deaths.html. It must be lined with cilia, hairlike projections like shag carpeting that move and clean the air we breathe in, he said. Ground-breaking work on synthetic organ transplants made Paolo Macchiarini one of the most famous doctors in the world. Ms. Sein speaking with Dr. Eric M. Genden Sr., left, who developed the pioneering procedure, and Dr. Sander S. Florman, director of Mount Sinais Transplantation Institute.

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